Triethylamine → HCID 66893102, compound

Participants

Reaction Steps

To a stirred solution of (3-(2,6-dimethylbenzyloxy)-4-fluorophenyl)methanol (Step B, 3.7 g, 14.21 mmol), triethylamine (5 g, 50 mmol) in CH2Cl2 (50 ml) was added mesyl chloride (10.34 g, 90.2 mmol) at 0° C. under argon. The reaction mixture was stirred for 6 hours, washed with 10% Na2CO3, dried over Na2SO4, filtered, concentrated and purified by flash chromatography on a silica gel column (hexane:ethyl acetate, 5:1) to give the title compound.

Provenance & Evidence