反应详情

To a solution of a diastereomeric mixture (330 mg, 0.55 mmol) of dibenzyl 3-(4-((tert-butyldimethylsilyl)oxy)cyclohexyl-2-cyclopentyl-2-hydroxysuccinate in ethanol (10 ml) was added 10% Pd carbon (150 mg) under a nitrogen gas stream. The atmosphere in a reaction vessel for the mixture was replaced five times with nitrogen gas, the reaction vessel was filled with hydrogen gas, and the contents of the reaction vessel were stirred for 24 hr under a hydrogen gas stream. The catalyst was collected by filtration through Celite pad and was washed with ethanol, and the filtrate was concentrated under reduced pressure to give the title compound as a colorless solid (190 mg, yield 83%).

1. customThe atmosphere in a reaction vessel for the mixture was replaced
2. filtrationThe catalyst was collected by filtration through Celite pad
3. washwas washed with ethanol
4. concentrationthe filtrate was concentrated under reduced pressure