HCID 178418361, compound → HCID 178455318, compound

Participants

Reaction Steps

To a solution of dibenzyl 2,3-bis(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)-2-hydroxysuccinate (500 mg, 0.38 mmol) in ethanol (15 ml) was added 10% Pd-carbon (150 mg) under a nitrogen gas stream. The atmosphere in the reaction vessel was replaced five times with nitrogen gas and was filled with hydrogen gas, and the contents in the reaction vessel were stirred under a hydrogen gas stream for 24 hr. The catalyst was collected by filtration through Celite pad and was washed with ethanol (50 ml×2). The filtrate was concentrated under reduced pressure to give the title compound as a colorless solid (275 mg, yield 73%).

Provenance & Evidence