反应详情

温度

120 °C

2-Hydroxy-2,3-bis(tetrahydro-2H-pyran-4-yl)succinic acid (1.2 g, 3.98 mmol) was dissolved in acetic anhydride (15 ml), and the solution was stirred at 120° C. for 24 hr. Excess acetic anhydride in the reaction mixture was removed by distillation under reduced pressure, and the residue was chromatographed on silica gel column (hexane:ethyl acetate=40:60) to give the title compound as a colorless solid (0.6 g, yield 60%).

1. customExcess acetic anhydride in the reaction mixture was removed by distillation under reduced pressure
2. customthe residue was chromatographed on silica gel column (hexane:ethyl acetate=40:60)