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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 516921Generated: October 26, 2026

Ethyl(methoxy)amine hydrochloride → 6-Chloro-3-(2-ethoxy-3,4-dioxo-cyclobut-1-enylamino)-2-hydroxy-N-(2-methoxy-ethoxy)-N-methyl-benzenesulfonamide

https://huagongshe.com/reaction/516921

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl(methoxy)amine hydrochlorideHCID 22613948—
ReactantO-(2-Methoxy-ethyl)-N-methyl-hydroxylamineHCID 53784863—
Reactant6-Chloro-3-(2-ethoxy-3,4-dioxo-cyclobut-1-enylamino)-2-hydroxy-N-methoxy-N-ethyl-benzenesulfonamideHCID 86638631—
Product6-Chloro-3-(2-ethoxy-3,4-dioxo-cyclobut-1-enylamino)-2-hydroxy-N-(2-methoxy-ethoxy)-N-methyl-benzenesulfonamideHCID 86638639—

Reaction Steps

This compound was prepared analogously to 6-chloro-3-(2-ethoxy-3,4-dioxo-cyclobut-1-enylamino)-2-hydroxy-N-methoxy-N-ethyl-benzenesulfonamide (Intermediate FA) by replacing N-ethyl-O-methylhydroxylamine hydrochloride (Intermediate G) with O-(2-Methoxy-ethyl)-N-methyl-hydroxylamine (Intermediate K). [M+H]+ 435

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09115087B2
Source datasetuspto-grants-2015_08
ORD IDord-e083c3ecd6234192bd9f209c25d1c27f
Source noteuspto-grants-2015_08