Diisopropylethylamine → HCID 66847757, 화합물

참여 물질

역할	이름	HCID	투입량
반응물	Diisopropylethylamine	HCID 81531	—
반응물	2-Chloro-1-[4-(naphthalene-2-sulfonyl)piperazin-1-yl]ethan-1-one	HCID 2405875	—
반응물	3-(4-(Trifluoromethyl)phenyl)propionic Acid	HCID 3588736	—
반응물	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
용매	Dichloromethane	HCID 6344	—
생성물	HCID 66847757	HCID 66847757	—

반응 단계

To a stirred solution of 2-chloro-1-(4-(naphthalen-2-ylsulfonyl)piperazin-1-yl)ethanone (compound 4, 0.086 g, 0.27 mmol) and 3-(4-(trifluoromethyl)phenyl)propanoic acid (60 mg, 0.27 mmol) in dry DCM (20 mL), DIPEA (72 mg, 1.37 mmol) followed by HATU (208 mg, 0.55 mmol) was added at room temperature and stirred overnight. The mixture was then diluted with DCM washed with water (2×10 mL) & brine (2×10 mL). The organic extract was dried over anhydrous sodium sulphate, filtered and concentrated under reduced pressure. The crude material was purified by column chromatography to yield the title compound AGI-604 (0.118 g, 90.07%) as solid.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09115086B2
출처 데이터셋	uspto-grants-2015_08
ORD ID	ord-c25316e7841046d8ba68d0c17ecb725e
출처 메모	uspto-grants-2015_08