HRID517051

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57475872

未命名化合物

反应SMILES：C[C@]1(c2cc(N)ccc2F)N=C(N)OC[C@@H]1F

HCID86672004

未命名化合物

PRODUCTS

产物

反应SMILES：C[C@]1(c2cc(NC(=O)c3ccc(OCC(F)F)cn3)ccc2F)N=C(N)OC[C@@H]1F

HCID66559186

未命名化合物

PROCEDURE

实验过程

The condensation of (4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate A8.2) and 5-(2,2-difluoro-ethoxy)-pyridine-2-carboxylic acid (CAS 1097730-45-4; WO2009091016) following procedure I yielded the title compound as a white foam. MS (ISP): m/z=427.2 [M+H]+.