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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 517052Generated: October 30, 2026

5-Cyclopropylpyridine-2-carboxylic acid → HCID 66558774, compound

https://huagongshe.com/reaction/517052

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Cyclopropylpyridine-2-carboxylic acidHCID 57827722—
Reactant(4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamineHCID 86672004—
ProductHCID 66558774HCID 66558774—

Reaction Steps

The condensation of (4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate A8.2) and 5-cyclopropyl-pyridine-2-carboxylic acid (CAS 1174322-66-7; WO2009091016) following procedure I yielded the title compound as a white solid. MS (ISP): m/z=387.3 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09115098B2
Source datasetuspto-grants-2015_08
ORD IDord-76da792ef58f4074bda8c6609da5efe7
Source noteuspto-grants-2015_08