HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-chloro-1,3-thiazole-5-carboxylic Acid → HCID 66558776, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-chloro-1,3-thiazole-5-carboxylic Acid | HCID 1481389 | — |
| Reactant | (4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine | HCID 86672004 | — |
| Product | HCID 66558776 | HCID 66558776 | — |
Reaction Steps
The condensation of (4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate A8.2) and 2-chloro-thiazole-5-carboxylic acid (CAS 101012-12-8) following procedure I yielded the title compound as a white solid. MS (ISP): m/z=387.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115098B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-8da4542c6f564b1681aed1fc93a74a16 |
| Source note | uspto-grants-2015_08 |