HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine → HCID 178421648, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine | HCID 86672004 | — |
| Reactant | HCID 178524948 | HCID 178524948 | — |
| Product | HCID 178421648 | HCID 178421648 | — |
Reaction Steps
The condensation of (4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate A8.2) and 4-chloro-1H-pyrazole-3-carboxylic acid (CAS 84547-87-5) following procedure I yielded the title compound as a white solid. MS (ISP): m/z=370.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115098B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-82d95c130fbe4ab188fe02c163c0f010 |
| Source note | uspto-grants-2015_08 |