HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Cyanopyridine-2-carboxylic acid → 5-Cyano-pyridine-2-carboxylic acid {3-[(4R,5R)-2-amino-4-methyl-5-(2,2,2-trifluoro-ethoxy)-5,6-dihydro-4H-[1,3]oxazin-4-yl]-4-fluoro-phenyl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Cyanopyridine-2-carboxylic acid | HCID 12400734 | — |
| Reactant | (4R,5R)-4-(5-amino-2-fluoro-phenyl)-4-methyl-5-(2,2,2-trifluoro-ethoxy)-5,6-dihydro-4H-[1,3]oxazin-2-ylamine | HCID 86672007 | — |
| Product | 5-Cyano-pyridine-2-carboxylic acid {3-[(4R,5R)-2-amino-4-methyl-5-(2,2,2-trifluoro-ethoxy)-5,6-dihydro-4H-[1,3]oxazin-4-yl]-4-fluoro-phenyl}-amide | HCID 66559015 | — |
Reaction Steps
The condensation of (4R,5R)-4-(5-amino-2-fluoro-phenyl)-4-methyl-5-(2,2,2-trifluoro-ethoxy)-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (A8.4) and 5-cyano-pyridine-2-carboxylic acid following procedure I yielded the title compound as a white solid. MS (ISP): m/z=452.1 [M+H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115098B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-37573de5a0d440208c7a363ea011ee90 |
| Source note | uspto-grants-2015_08 |