5-(2,2,2-Trifluoroethoxy)pyridine-2-carboxylic acid → 5-(2,2,2-Trifluoro-ethoxy)-pyridine-2-carboxylic acid {3-[(4R,5R)-2-amino-4-methyl-5-(2,2,2-trifluoro-ethoxy)-5,6-dihydro-4H-[1,3]oxazin-4-yl]-4-fluoro-phenyl}-amide

Participants

Role	Name	HCID	Charge
Reactant	5-(2,2,2-Trifluoroethoxy)pyridine-2-carboxylic acid	HCID 57475854	—
Reactant	(4R,5R)-4-(5-amino-2-fluoro-phenyl)-4-methyl-5-(2,2,2-trifluoro-ethoxy)-5,6-dihydro-4H-[1,3]oxazin-2-ylamine	HCID 86672007	—
Product	5-(2,2,2-Trifluoro-ethoxy)-pyridine-2-carboxylic acid {3-[(4R,5R)-2-amino-4-methyl-5-(2,2,2-trifluoro-ethoxy)-5,6-dihydro-4H-[1,3]oxazin-4-yl]-4-fluoro-phenyl}-amide	HCID 66559100	—

Reaction Steps

The condensation of (4R,5R)-4-(5-amino-2-fluoro-phenyl)-4-methyl-5-(2,2,2-trifluoro-ethoxy)-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (A8.4) and 5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid following procedure I yielded the title compound as a white solid. MS (ISP): m/z=525.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09115098B2
Source dataset	uspto-grants-2015_08
ORD ID	ord-c26b0a213f48423581fdeef6f7913d39
Source note	uspto-grants-2015_08