HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxybut-1-yne → 2,2,2-Trifluoro-n-(3-hydroxy-3-(3-(4-methoxybut-1-ynyl)phenyl)propyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxybut-1-yne | HCID 542152 | — |
| Reactant | N-(3-(3-bromophenyl)-3-hydroxypropyl)-2,2,2-trifluoroacetamide | HCID 57608426 | — |
| Product | 2,2,2-Trifluoro-n-(3-hydroxy-3-(3-(4-methoxybut-1-ynyl)phenyl)propyl)acetamide | HCID 87082489 | — |
Reaction Steps
Sonogashira reaction of 25 with 4-methoxy-but-1-yne yielded 2,2,2-trifluoro-N-(3-hydroxy-3-(3-(4-methoxybut-1-ynyl)phenyl)propyl)acetamide as a dark yellow oil. Yield (0.51 g, 51%). Compound could not be purified completely and was forwarded as such into the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115056B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-fb237bfee877492c89c4bbee9e25734b |
| Source note | uspto-grants-2015_08 |