HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 3-Hydroxy-3-(3-iodophenyl)propanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 3-Iodobenzaldehyde | HCID 252610 | — |
| Product | 3-Hydroxy-3-(3-iodophenyl)propanenitrile | HCID 57608423 | — |
Reaction Steps
Acetonitrile addition to 3-iodobenzaldehyde (103) yielded 3-hydroxy-3-(3-iodophenyl)propanenitrile (104) as yellow oil. Yield (2.58 g, 55%): 1H NMR (400 MHz, CDCl3) 7.82 (s, 1H), 7.70 (d, J=8.0 Hz, 1H), 7.38 (d, J=8.0 Hz, 1H), 7.14 (t, J=8.0 Hz, 1H), 5.01 (m, 1H), 2.80 (d, J=6.4, 2H), 2.40 (bs, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115056B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-8970f74e5a8645b5b6a44ece0da611d3 |
| Source note | uspto-grants-2015_08 |