HCID 86732302, compound → HCID 86732305, compound

HRID 517186Notes

Reaction equation

HRID 517186 reaction equation
[C:1]([C:3]1C=CC(C(C2C(=O)CC(C(F)(F)F)CC=2OCC)NC(NC2C=CC=C(C(F)(F)F)C=2)=O)=CC=1)#N.[C:38]([C:40]1[CH:45]=[CH:44][C:43]([CH:46]([C:61]2[C:66](=[O:67])[CH2:65][CH:64]([C:68]3[CH:73]=[CH:72][C:71]([C:74]([F:77])([F:76])[F:75])=[CH:70][CH:69]=3)[CH2:63][C:62]=2[OH:78])[NH:47][C:48]([NH:50][C:51]2[CH:56]=[CH:55][CH:54]=[C:53]([C:57]([F:60])([F:59])[F:58])[CH:52]=2)=[O:49])=[CH:42][CH:41]=1)#[N:39]>>[C:38]([C:40]1[CH:41]=[CH:42][C:43]([CH:46]([C:61]2[C:66](=[O:67])[CH2:65][CH:64]([C:68]3[CH:69]=[CH:70][C:71]([C:74]([F:75])([F:76])[F:77])=[CH:72][CH:73]=3)[CH2:63][C:62]=2[O:78][CH2:1][CH3:3])[NH:47][C:48]([NH:50][C:51]2[CH:56]=[CH:55][CH:54]=[C:53]([C:57]([F:60])([F:59])[F:58])[CH:52]=2)=[O:49])=[CH:44][CH:45]=1)#[N:39]

Participants

3

Reactant 2

HCID 86732302HCID 86732302, compound2×HCID 86732304HCID 86732304, compound2×

Product 1

HCID 86732305HCID 86732305, compound

Procedure

The title compound is prepared in analogy to 1-((4-cyanophenyl)(2-ethoxy-6-oxo-4-(tri-fluoromethyl)cyclohex-1-enyl)methyl)-3-(3-(trifluoromethyl)phenyl)urea (intermediate 13), using 1-((4-cyanophenyl)(2-hydroxy-6-oxo-4-(4-(trifluoromethyl)phenyl)cyclohex-1-enyl)-methyl)-3-(3-(trifluoromethyl)phenyl)urea (intermediate 16, 930 mg, 1.62 mmol) as starting material. Yield: 825 mg; ESI mass spectrum [M+H]+=602, Retention time HPLC: 1.37 min (V011_S01).

Workup

  1. custom1.37 min (V011_S01)

Sources & evidence

ORD record
ord-0ca0ba652c294625a827e1d54601dabe
Source dataset
uspto-grants-2015_08
Patent number
US09115093B2

Reaction notes

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