Diisopropylethylamine → HCID 86732316, compound

Participants

Reaction Steps

Trimethyloxonium tetrafluoroborate (47 mg, 0.318 mmol) is added to a solution of N,N-diisopropylethylamine (72 μL, 0.412 mmol) and 1-((4-cyanophenyl)(2-hydroxy-6-oxocyclohex-1-enyl)methyl)-3-(2-(trifluoromethyl)pyridin-4-yl)urea (intermediate 26, 90 mg, 0.209 mmol) in dichloromethane (10 mL). The mixture is stirred at room temperature for 1 h and extracted three times with water. The organic phase is dried over Na2SO4 and concentrated under reduced pressure. Yield: 100 mg; ESI mass spectrum [M+H]+=445, Retention time HPLC: 1.05 min (V012_S01).

Provenance & Evidence