HRID517198

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC1=C(C(NC(=O)Nc2cc(C(F)(F)F)ccn2)c2ccc(C#N)cc2)C(=O)CCC1

HCID86732313

未命名化合物

2 次

结构：N#Cc1ccc(C(NC(=O)Nc2cccc(C(F)(F)F)c2)C2=C(O)CCCC2=O)nc1

HCID86732317

未命名化合物

2 次

PRODUCTS

生成物

结构：COC1=C(C(NC(=O)Nc2cccc(C(F)(F)F)c2)c2ccc(C#N)cn2)C(=O)CCC1

HCID86732318

未命名化合物

PROCEDURE

实验过程

The title compound is prepared in analogy to 1-((4-cyanophenyl)(2-methoxy-6-oxocyclohex-1-enyl)methyl)-3-(4-(trifluoromethyl)pyridin-2-yl)urea (intermediate 25) using 1-((5-cyanopyridin-2-yl)(2-hydroxy-6-oxocyclohex-1-enyl)methyl)-3-(3-(trifluoromethyl)phenyl) urea (intermediate 28, 330 mg, 0.767 mmol) as starting material. Yield: 203 mg; ESI mass spectrum [M+H]+=445, Retention time HPLC: 1.05 min (V011_S01).

WORKUP

后处理

custom1.05 min (V011_S01)