HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-[4-(1-Benzyloxycyclopropyl)-phenylethynyl]-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl4-[4-(1-benzyloxycyclopropyl)-phenylethynyl]-benzoate | HCID 22568905 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-[4-(1-Benzyloxycyclopropyl)-phenylethynyl]-benzoic acid | HCID 10133626 | 89% |
Reaction Steps
Using General Procedure I; a solution of ethyl 4-[4-(1-benzyloxycyclopropyl)-phenylethynyl]-benzoate (Compound 75, 78.0 mg, 0.20 mmol) in ethanol (3 mL) and tetrahydrofuran (3 mL) was treated with NaOH (80.0 mg, 2.0 mmols, 2.0 mL of a 1N aqueous solution) and stirred overnight at room temperature. Work-up afforded 65.0 mg (89%) of the title compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06713647B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-f0a73c3c9a8240acb44d814df212bb02 |
| Source note | uspto-grants-2004_03 |