反应详情

Water (10 mL) is added dropwise to a mixture of 3-(difluoromethyl)aniline (2.00 g, 13.97 mmol) in glacial acetic acid (6 mL). A solution of sodium cyanate (1.00 g, 15.38 mmol) in water (10 mL) is added dropwise, and the mixture is stirred at room temperature for 4 h. The precipitate is filtered, washed with water and dried under reduced pressure. Yield: 1.80 g; ESI mass spectrum [M+H]+=187, Retention time HPLC: 0.70 min (Z012_S04).

1. filtrationThe precipitate is filtered
2. washwashed with water
3. customdried under reduced pressure
4. custom0.70 min (Z012_S04)