Sodium Cyanate → HCID 68639572, compound

HRID 517204Notes

Reaction equation

HRID 517204 reaction equation
[F:1][CH:2]([F:10])[C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][CH:9]=1)[NH2:6].[O-:11][C:12]#[N:13].[Na+]>C(O)(=O)C.O>[F:1][CH:2]([F:10])[C:3]1[CH:4]=[C:5]([NH:6][C:12]([NH2:13])=[O:11])[CH:7]=[CH:8][CH:9]=1

Participants

5

Reactant 2

HCID 517096Sodium CyanateHCID 234451193-(Difluoromethyl)aniline

Product 1

HCID 68639572HCID 68639572, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent2×

Procedure

Water (10 mL) is added dropwise to a mixture of 3-(difluoromethyl)aniline (2.00 g, 13.97 mmol) in glacial acetic acid (6 mL). A solution of sodium cyanate (1.00 g, 15.38 mmol) in water (10 mL) is added dropwise, and the mixture is stirred at room temperature for 4 h. The precipitate is filtered, washed with water and dried under reduced pressure. Yield: 1.80 g; ESI mass spectrum [M+H]+=187, Retention time HPLC: 0.70 min (Z012_S04).

Workup

  1. filtrationThe precipitate is filtered
  2. washwashed with water
  3. customdried under reduced pressure
  4. custom0.70 min (Z012_S04)

Sources & evidence

ORD record
ord-e78ad9d3377f4f41b7eab9da9e186640
Source dataset
uspto-grants-2015_08
Patent number
US09115093B2

Reaction notes

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