HRID517239

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CS(=O)(=O)c1cc(Br)ccc1C1NC(=O)N(c2cccc(C(F)F)c2)C2=C1C(=O)CCC2

HCID86732324

未命名化合物

2 次

结构：CS(=O)(=O)c1cc(C#N)ccc1C1NC(=O)N(c2cccc(C(F)(F)F)c2)C2=C1C(=O)CCC2

HCID86732328

未命名化合物

PRODUCTS

生成物

结构：CS(=O)(=O)c1cc(C#N)ccc1C1NC(=O)N(c2cccc(C(F)F)c2)C2=C1C(=O)CCC2

HCID86732360

未命名化合物

PROCEDURE

实验过程

The title compound is prepared in analogy to 4-(2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)-3-(methyl sulfonyl)benzonitrile (example 18), using 4-(4-bromo-2-(methylsulfonyl)phenyl)-1-(3-(difluoromethyl)phenyl)-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione (intermediate 36) as starting material. Yield: 185 mg; ESI mass spectrum [M+H]+=472; Retention time HPLC: 0.93 min (Z012_S04).

WORKUP

后处理

custom0.93 min (Z012_S04)