3851-91-0 → HCID 86673314, compound

HRID 517325Notes

Reaction equation

HRID 517325 reaction equation
[CH:1]([O:4][S:5]([CH:8]=[CH2:9])(=[O:7])=[O:6])([CH3:3])[CH3:2].[CH:10]([Si:13]([CH:22]([CH3:24])[CH3:23])([CH:19]([CH3:21])[CH3:20])[O:14][CH2:15][CH2:16][CH2:17][NH2:18])([CH3:12])[CH3:11]>CO>[CH:1]([O:4][S:5](=[O:7])(=[O:6])[CH2:8][CH2:9][NH:18][CH2:17][CH2:16][CH2:15][O:14][Si:13]([CH:22]([CH3:24])[CH3:23])([CH:10]([CH3:12])[CH3:11])[CH:19]([CH3:21])[CH3:20])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 122599943851-91-0HCID 86003215HCID 86003215, compound

Product 1

HCID 86673314HCID 86673314, compoundYield 85.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Vinylsulfonic acid isopropyl ester (0.3 g, 2.00 mmol) obtained in step 1 and 3-triisopropylsilyloxypropylamine (0.9 g, 3.89 mmol) were dissolved in methanol (10 mL), and the mixture was stirred at room temperature overnight. The solvent was evaporated and the residue was purified by silica gel column chromatography to give the title compound (0.65 g).

Workup

  1. customThe solvent was evaporated
  2. customthe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-1d683bd0464b4a138401a354bc2c9535
Source dataset
uspto-grants-2015_08
Patent number
US09115107B2

Reaction notes

Loading…