5-(2-tert-Butoxycarbonylethenyl)furan-2-carboxylic acid benzyl ester → 5-(2-Tert-butoxycarbonylethyl)-furan-2-carboxylic acid

HRID 517335노트

반응식

HRID 517335 반응식
C([O:8][C:9]([C:11]1[O:12][C:13]([CH:16]=[CH:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])=[CH:14][CH:15]=1)=[O:10])C1C=CC=CC=1>CO.[Pd]>[C:21]([O:20][C:18]([CH2:17][CH2:16][C:13]1[O:12][C:11]([C:9]([OH:10])=[O:8])=[CH:15][CH:14]=1)=[O:19])([CH3:24])([CH3:22])[CH3:23]

참가 물질

4

반응물 1

HCID 779345505-(2-tert-Butoxycarbonylethenyl)furan-2-carboxylic acid benzyl ester

생성물 1

HCID 683202805-(2-Tert-butoxycarbonylethyl)-furan-2-carboxylic acid수율 98.1%

시약·촉매·용매 2

HCID 23938Palladium촉매2회HCID 887Methanol용매

실험 절차

5-(2-tert-Butoxycarbonylethenyl)furan-2-carboxylic acid benzyl ester (0.97 g, 2.80 mmol) was dissolved in methanol (50 mL), 10% palladium/carbon (0.1 g) was added, and the mixture was stirred at room temperature for 2 hours under a hydrogen atmosphere. After completion of the reaction, palladium/carbon was removed by celite filtration, and the solvent was evaporated under reduced pressure to give the title compound (0.66 g).

후처리

  1. customwas removed by celite filtration
  2. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-e7c0d81102d6472c93308fb83da8b77b
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09115107B2

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