HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 517366Generated: October 28, 2026
ethyl 3-chloro-1-(pyridin-3-yl)-4,5-dihydro-1H-pyrazole-5-carboxylate → ethyl 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-5-carboxylate
https://huagongshe.com/reaction/517366
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | ethyl 3-chloro-1-(pyridin-3-yl)-4,5-dihydro-1H-pyrazole-5-carboxylate | HCID 118021759 | — |
| Catalyst | HCID 178418406 | HCID 178418406 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | ethyl 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-5-carboxylate | HCID 118022610 | — |
Reaction Steps
In a preferred reaction, ethyl 3-chloro-1-(pyridin-3-yl)-4,5-dihydro-1H-pyrazole-5-carboxylate (10b) and acetonitrile are mixed with manganese(IV) oxide and the mixture is heated at about 60° C. until the reaction is completed. The ethyl 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-5-carboxylate (10c) is conveniently isolated and purified by standard techniques.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09115115B1 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-a8ab26a2ca434c94874c1ace3b9e5bc7 |
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| Source note | uspto-grants-2015_08 |
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