反应详情

温度

52.5 °C

S-1,1′-bi-2-naphthol (124 gm) was added to a solution of omeprazole (100 gm) in a mixture of toluene and cyclohexane (2000 ml, 4:1) at room temperature. The reaction mixture was heated to 50 to 55° C. and maintained for 1 hour at 50 to 55° C. The solution was cooled to room temperature and filtered, washed with a mixture of toluene and cyclohexane (200 ml, 4:1). The solid was dried at 45 to 50° C. under vacuum for 4 hours to obtain 80 gm of esomeprazole-S-BINOL complex.

1. temperaturemaintained for 1 hour at 50 to 55° C
2. temperatureThe solution was cooled to room temperature
3. filtrationfiltered
4. washwashed with a mixture of toluene and cyclohexane (200 ml, 4:1)
5. customThe solid was dried at 45 to 50° C. under vacuum for 4 hours
6. customto obtain 80 gm of esomeprazole-S-BINOL complex