HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 51744Generated: October 29, 2026
Trimethylsilylacetylene → HCID 22568952, compound
https://huagongshe.com/reaction/51744
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trimethylsilylacetylene | HCID 66111 | — |
| Reactant | 4-Bromo-1-(1-isopropoxycyclopropyl)-2-ethyl-benzene | HCID 22568948 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 22568952 | HCID 22568952 | 99.5% |
Reaction Steps
Using General Procedure D; 4-bromo-1-(1-isopropoxycyclopropyl)-2-ethyl-benzene (Intermediate 93, 300.0 mg, 1.07 mmol) in triethylamine (8 mL) was treated with copper(I)iodide (20.0 mg, 0.11 mmol) and then sparged with argon for 5 minutes. Trimethylsilylacetylene (0.70 g, 7.1 mmols) was then added followed by dichlorobis-(triphenylphosphine)palladium(II) (75.0 mg, 0.11 mmol). The resulting reaction mixture was heated to 70° C. for 5 d. The title compound (320.0 mg, 99%) was isolated by chromatography (0-2% EtOAc-hexanes) as an orange oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06713647B2 |
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| Source dataset | uspto-grants-2004_03 |
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| ORD ID | ord-8290f05e3c334e858253b9c08c0d1cb3 |
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| Source note | uspto-grants-2004_03 |
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