HCID 51029905, compound → HCID 51029907, compound

HRID 517508Notes

Reaction equation

HRID 517508 reaction equation
C(OC1C=CC(C(NC[C@H](N2CCN(S(C)(=O)=O)CC2)C(O)=O)=O)=CC=1)CCC.[CH2:30]([O:37][C:38]1[CH:62]=[CH:61][C:41]([C:42]([NH:44][CH2:45][C@@H:46]([C:57](=[O:60])[NH:58][OH:59])[N:47]2[CH2:52][CH2:51][N:50]([S:53]([CH3:56])(=[O:55])=[O:54])[CH2:49][CH2:48]2)=[O:43])=[CH:40][CH:39]=1)[C:31]1C=CC=[CH:33][CH:32]=1>>[CH2:30]([O:37][C:38]1[CH:39]=[CH:40][C:41]([C:42]([NH:44][CH2:45][C@@H:46]([C:57](=[O:60])[NH:58][OH:59])[N:47]2[CH2:48][CH2:49][N:50]([S:53]([CH3:56])(=[O:54])=[O:55])[CH2:51][CH2:52]2)=[O:43])=[CH:61][CH:62]=1)[CH2:31][CH2:32][CH3:33]

Participants

3

Reactant 2

HCID 51029905HCID 51029905, compoundHCID 67057012HCID 67057012, compound

Product 1

HCID 51029907HCID 51029907, compound

Procedure

In a manner similar to example 2-6, starting from 200 mg (0.5 mmol) of (S)-3-(4-butoxybenzoylamino)-2-(4-methanesulphonylpiperazin-1-yl)propanoic acid, 100 mg (55%) of 4-benzyloxy-N—[(S)-2-hydroxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)ethyl]benzamide are obtained in the form of a beige solid having a melting point of 130° C.

Workup

  1. customare obtained in the form of a beige solid

Sources & evidence

ORD record
ord-ab914e010e8f4957a2e8230dd60adee9
Source dataset
uspto-grants-2015_08
Patent number
US09115102B2

Reaction notes

Loading…