HCID 67056977, compound → HCID 68088466, compound

HRID 517511Notes

Reaction equation

HRID 517511 reaction equation
[CH3:1][S:2]([N:5]1[CH2:10][CH2:9][N:8]([C@@H:11]([CH2:16][NH:17][C:18](=[O:37])[C:19]2[CH:24]=[CH:23][C:22]([O:25][CH2:26][C:27]3[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][CH:28]=3)=[CH:21][CH:20]=2)[C:12]([O:14]C)=[O:13])[CH2:7][CH2:6]1)(=[O:4])=[O:3].CS(N1CCN([C@@H](CNC(=O)C2C=CC(OCC3C=CC(F)=CC=3)=CC=2)C(O)=O)CC1)(=O)=O>>[CH3:1][S:2]([N:5]1[CH2:6][CH2:7][N:8]([C@@H:11]([CH2:16][NH:17][C:18](=[O:37])[C:19]2[CH:20]=[CH:21][C:22]([O:25][CH2:26][C:27]3[CH:32]=[CH:31][C:30]([C:33]([F:34])([F:35])[F:36])=[CH:29][CH:28]=3)=[CH:23][CH:24]=2)[C:12]([OH:14])=[O:13])[CH2:9][CH2:10]1)(=[O:3])=[O:4]

Participants

3

Reactant 2

HCID 67056977HCID 67056977, compoundHCID 67056980HCID 67056980, compound

Product 1

HCID 68088466HCID 68088466, compound

Procedure

In a manner similar to example 2-5, starting from 240 mg (0.4 mmol) of methyl (S)-2-(4-methanesulphonylpiperazin-1-yl)-3-[4-(4-trifluoromethylbenzyloxy)-benzoylamino]propanoate, 200 mg (82%) of (S)-2-(4-methanesulphonylpiperazin-1-yl)-3-[4-(4-fluorobenzyl-oxy)benzoylamino]propanoic acid are obtained in the form of a white solid.

Workup

  1. customare obtained in the form of a white solid

Sources & evidence

ORD record
ord-26b0cdbce3e442fab30debb93e5b584e
Source dataset
uspto-grants-2015_08
Patent number
US09115102B2

Reaction notes

Loading…