4-Methoxybenzyl bromide → methyl (S)-2-(4-methanesulphonylpiperazin-1-yl)-3-[4-(4-methoxybenzyloxy)benzoylamino]propanoate

Participants

Reaction Steps

In a manner similar to example 4-5, starting from 300 mg (0.8 mmol) of methyl (S)-3-(4-hydroxybenzoylamino)-2-(4-methanesulphonylpiperazin-1-yl)propanoate (prepared as described in example 4-4) and from 0.14 ml (0.9 mmol) of 1-bromomethyl-4-methoxybenzene; 390 mg (100%) of methyl (S)-2-(4-methanesulphonylpiperazin-1-yl)-3-[4-(4-methoxybenzyloxy)benzoylamino]propanoate are obtained in the form of a colourless oil.

Provenance & Evidence