HCID 86667912, compound → HCID 67056938, compound

Participants

Reaction Steps

520 mg of 10 wt % palladium on carbon are added to a solution of 5.2 g (10.7 mmol) of methyl (S)-2-(4-benzylpiperazin-1-yl)-3-[4-(2-methoxyethoxymethoxy)-benzoylamino]propanoate (prepared as described in example 22-4) in 80 ml of ethanol previously degassed under a stream of nitrogen, and the mixture is placed under hydrogen at atmospheric pressure. After stirring for 18 h at ambient temperature, the reaction medium is filtered over celite. The filtrate is concentrated to give 3.8 g (90%) of methyl (S)-3-[4-(2-methoxyethoxy-methoxy)benzoylamino]-2-piperazin-1-ylpropanoate in the form of a colourless oil.

Provenance & Evidence