2-Propanesulfonyl chloride → HCID 67056986, compound

HRID 517517Notes

Reaction equation

HRID 517517 reaction equation
[CH3:1][CH:2]([S:4](Cl)(=[O:6])=[O:5])[CH3:3].[CH3:8][O:9][CH2:10][CH2:11][O:12][CH2:13][O:14][C:15]1[CH:35]=[CH:34][C:18]([C:19]([NH:21][CH2:22][C@H:23]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[C:24]([O:26][CH3:27])=[O:25])=[O:20])=[CH:17][CH:16]=1>>[CH3:8][O:9][CH2:10][CH2:11][O:12][CH2:13][O:14][C:15]1[CH:35]=[CH:34][C:18]([C:19]([NH:21][CH2:22][C@H:23]([N:28]2[CH2:29][CH2:30][N:31]([S:4]([CH:2]([CH3:3])[CH3:1])(=[O:6])=[O:5])[CH2:32][CH2:33]2)[C:24]([O:26][CH3:27])=[O:25])=[O:20])=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 824082-Propanesulfonyl chlorideHCID 67056938HCID 67056938, compound

Product 1

HCID 67056986HCID 67056986, compoundYield 68%

Procedure

In a manner similar to example 2-1, starting from 0.2 ml (1.9 mmol) of 2-propanesulphonyl chloride and from 0.7 g (1.8 mmol) of methyl (S)-3-[4-(2-methoxy-ethoxymethoxy)benzoylamino]-2-piperazin-1-ylpropanoate, 0.6 g (68%) of methyl (S)-3-[4-(2-methoxyethoxy-methoxy)benzoylamino]-2-[4-(propane-2-sulphonyl)-piperazin-1-yl]propanoate is obtained in the form of a colourless oil.

Sources & evidence

ORD record
ord-69c551a0c6d94445bff37f95cfded2a2
Source dataset
uspto-grants-2015_08
Patent number
US09115102B2

Reaction notes

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