Hydrochloric Acid → HCID 51030560, compound

Participants

Reaction Steps

300 μl of a 5/6N solution of hydrochloric acid in isopropanol are added to a solution of 300 mg (0.6 mmol) of N—[(S)-2-hydroxycarbamoyl-2-(4-methane-sulphonylpiperazin-1-yl)ethyl]-4-(2-methylquinolin-4-yl-methoxy)benzamide (prepared as described in example 14.3) in 6 ml of isopropanol. After stirring at ambient temperature for 2 h, the reaction medium is filtered. The solid is rinsed with isopropanol then recrystallized in a water/isopropanol mixture, filtered and dried under vacuum. 261 mg (34%) of N—[(S)-2-hydroxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)-ethyl]-4-(2-methylquinolin-4-ylmethoxy)benzamide dihydrochloride are obtained in the form of a white solid.

Provenance & Evidence