Sodium Bromide → 3-Bromo-1-(3-bromophenyl)butan-2-one

HRID 517551Notes

Reaction equation

HRID 517551 reaction equation
[Na+].[Br-:2].[Br:3][C:4]1[CH:5]=[C:6]([CH2:10][C:11](=[O:15])[CH:12](Cl)[CH3:13])[CH:7]=[CH:8][CH:9]=1>CC(C)=O.CCCCCC>[Br:2][CH:12]([CH3:13])[C:11](=[O:15])[CH2:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([Br:3])[CH:5]=1

Participants

5

Reactant 2

HCID 253881Sodium BromideHCID 867114911-(3-Bromophenyl)-3-chlorobutan-2-one

Product 1

HCID 867114923-Bromo-1-(3-bromophenyl)butan-2-one

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 8058HexaneSolvent

Conditions

Temperature
70 °C

Procedure

A mixture of NaBr (197 mg, 1.9 mmol) and 1-(3-bromophenyl)-3-chlorobutan-2-one (100 mg, 0.38 mmol) in acetone (2 ml) was stirred at 70° C. for 3 h. The mixture was diluted with hexane and filtered to remove the solid. The solvent was removed under reduced pressure and the residue was used for the next step without further purification. MS (ES+) C10H10Br2O requires: 303, 305 found: 304, 306 [M+H]+(1:1).

Workup

  1. filtrationfiltered
  2. customto remove the solid
  3. customThe solvent was removed under reduced pressure
  4. customthe residue was used for the next step without further purification

Sources & evidence

ORD record
ord-8d51c3e1bfe7421f991cd64aee8c6583
Source dataset
uspto-grants-2015_08
Patent number
US09115120B2

Reaction notes

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