Piperidine → (5Z)-5-(4-ethoxybenzylidene)-2-sulfanyl-1,3-thiazol-4(5H)-one

Participants

Reaction Conditions

Reaction Steps

4-Ethoxybenzaldehyde (2.78 mL, 20.00 mmol) and rhodanine 7 (3.75 g, 32.0 mmol) were dissolved in 80 mL of anhydrous ethanol at room temperature, and piperidine (0.60 mL, 6.0 mmol) was added to the reaction flask. The reaction mixture was stirred at 75° C. for 1 day and then allowed to cool down to room temperature until a yellow crystalline precipitate formed, and the solid was collected by filtration, washed with water and ethyl acetate, and dried to afford compound 8 in 80.0% (2.99 g) yield as a yellow solid.

Provenance & Evidence