Potassium Carbonate → HCID 71697075, compound

Participants

Reaction Steps

Potassium carbonate (180 mg, 1.30 mmol) was added to a solution of compound 12 (100 mg, 0.43 mmol) in 3 mL of anhydrous DMF at 0° C. After stirring the reaction mixture for 20 min, a solution of tert-butyl (2-bromoethyl)carbamate (96 mg, 0.43 mmol) in anhydrous DMF (1 mL) was added and then the reaction mixture was stirred at room temperature for 3 h. The reaction was quenched by adding water and extracted with ethyl acetate. The ethyl acetate layer was washed with 10% NH4Cl aqueous solution followed by water and dried over anhydrous Na2SO4, filtered, concentrated and purified by silica column chromatography (20% ethyl acetate in hexanes) to afford 70 mg (43.2%) of Boc-protected 13 as a white solid.

Provenance & Evidence