HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → (Z)-3-(2-(benzylamino)ethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione | HCID 1249836 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | (Z)-5-(4-ethoxybenzylidene)-3-(2-(methylamino)ethyl)thiazolidine-2,4-dione | HCID 71697257 | — |
| Product | (Z)-3-(2-(benzylamino)ethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione | HCID 71697260 | — |
Reaction Steps
The title compound 23d was prepared from compound 76 (204 mg, 0.70 mmol), benzaldehyde (71 μL, 0.70 mmol) and sodium triacetoxyborohydride (445 mg, 2.10 mmol) in a manner similar to that described for 23a in 46.0% (123 mg) yield as a light-yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115122B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-1bf91229b8424ad5b8e88fca24918543 |
| Source note | uspto-grants-2015_08 |