HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyl chloroformate → (Z)-isobutyl (2-(5-(4-ethoxybenzylidene)-2,4-dioxothiazolidin-3-yl)ethyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyl chloroformate | HCID 62365 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione | HCID 1249836 | — |
| Reactant | (Z)-N-(2-(5-(4-ethoxybenzylidene)-2,4-dioxothiazolidin-3-yl)ethyl)acetamide | HCID 45485995 | — |
| Product | (Z)-isobutyl (2-(5-(4-ethoxybenzylidene)-2,4-dioxothiazolidin-3-yl)ethyl)carbamate | HCID 71697448 | — |
Reaction Steps
The title compound 26c was prepared from compound 76 (70 mg, 0.17 mmol), isobutyl chloroformate (25 μL, 0.19 mmol) and DIPEA (75 μL, 0.43 mmol) in a manner similar to that described for 25a in 96.4% (65 mg) yield as a light-yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115122B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-9730467e9dde4962b6d4a1e1fc08e78e |
| Source note | uspto-grants-2015_08 |