HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonyl chloride → (Z)-N-(2-(5-(4-ethoxybenzylidene)-2,4-dioxothiazolidin-3-yl)ethyl)methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione | HCID 1249836 | — |
| Reactant | (Z)-N-(2-(5-(4-ethoxybenzylidene)-2,4-dioxothiazolidin-3-yl)ethyl)acetamide | HCID 45485995 | — |
| Product | (Z)-N-(2-(5-(4-ethoxybenzylidene)-2,4-dioxothiazolidin-3-yl)ethyl)methanesulfonamide | HCID 71697451 | — |
Reaction Steps
The title compound 27a was prepared from compound 76 (101 mg, 0.25 mmol), methylsulfonyl chloride (21 μL, 028 mmol) and DIPEA (131 μL, 0.75 mmol) in a manner similar to that described for 25a in 96.2% (89 mg) yield as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115122B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-52fd36a4359a4e938ab11117fc6094a3 |
| Source note | uspto-grants-2015_08 |