HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Cyanobenzenesulfonyl chloride → (Z)-4-cyano-N-(2-(5-(4-ethoxybenzylidene)-2,4-dioxothiazolidin-3-yl)ethyl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Cyanobenzenesulfonyl chloride | HCID 39497 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione | HCID 1249836 | — |
| Reactant | (Z)-N-(2-(5-(4-ethoxybenzylidene)-2,4-dioxothiazolidin-3-yl)ethyl)acetamide | HCID 45485995 | — |
| Product | (Z)-4-cyano-N-(2-(5-(4-ethoxybenzylidene)-2,4-dioxothiazolidin-3-yl)ethyl)benzenesulfonamide | HCID 71697549 | — |
Reaction Steps
The title compound 27b was prepared from compound 76 (101 mg, 0.25 mmol), 4-cyano-benzenesulfonyl chloride (55 mg, 0.28 mmol) and DIPEA (131 μL, 0.75 mmol) in a manner similar to that described for 25a in 92.0% (105 mg) yield as a light-yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115122B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-79e58ebdcc4f43e4b6f93a211baa9b35 |
| Source note | uspto-grants-2015_08 |