HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → (Z)-N-(2-(5-(4-ethoxybenzylidene)-2,4-dioxothiazolidin-3-yl)ethyl)-1-methyl-1H-imidazole-4-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione | HCID 1249836 | — |
| Reactant | 1-methyl-1H-imidazole-4-sulfonyl chloride | HCID 2736887 | — |
| Reactant | (Z)-N-(2-(5-(4-ethoxybenzylidene)-2,4-dioxothiazolidin-3-yl)ethyl)acetamide | HCID 45485995 | — |
| Product | (Z)-N-(2-(5-(4-ethoxybenzylidene)-2,4-dioxothiazolidin-3-yl)ethyl)-1-methyl-1H-imidazole-4-sulfonamide | HCID 71697550 | — |
Reaction Steps
The title compound 27c was prepared from compound 76 (101 mg, 0.25 mmol), 1-methylimidazole-4-sulfonyl chloride (50 mg, 0.28 mmol) and DIPEA (131 μL, 0.75 mmol) in a manner similar to that described for 25a in 98.0% (108 mg) yield as a light-yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115122B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-7b1c7bd0442d4197a204fb765544cf4d |
| Source note | uspto-grants-2015_08 |