HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylene Glycol → (Z)-5-(4-ethoxybenzylidene)-3-(2-hydroxyethyl)thiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Diisopropyl azodicarboxylate | HCID 5363146 | — |
| Reactant | (Z)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione | HCID 5878179 | — |
| Product | (Z)-5-(4-ethoxybenzylidene)-3-(2-hydroxyethyl)thiazolidine-2,4-dione | HCID 71697555 | — |
Reaction Steps
The title compound 28e was prepared from compound 2 (249 mg, 1.00 mmol), ethane-1,2-diol (111 μL, 2.00 mmol), triphenylphosphine (524 mg, 2.00 mmmol) and DIAD (394 μL, 2.00 mmol) in a manner similar to that described for 9 in 95.2% (279 mg) yield as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115122B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-13a5e5ba41af4038b9151d64720bcf46 |
| Source note | uspto-grants-2015_08 |