HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (Z)-5-(4-ethoxybenzylidene)-3-(pyridin-3-ylmethyl)thiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(Chloromethyl)pyridine | HCID 18358 | — |
| Reactant | (Z)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione | HCID 5878179 | — |
| Reactant | (Z)-5-(4-ethoxybenzylidene)-3-propylthiazolidine-2,4-dione | HCID 71697554 | — |
| Product | (Z)-5-(4-ethoxybenzylidene)-3-(pyridin-3-ylmethyl)thiazolidine-2,4-dione | HCID 71697660 | — |
Reaction Steps
The title compound 28k was prepared from compound 2 (75 mg, 0.30 mmol), 3-picolyl chloride.HCl (54 mg, 0.33 mmol), sodium iodide (45 mg, 0.30 mmol) and potassium carbonate (124 mg, 0.90 mmol) in a manner similar to that described for 28d in 93.1% (95 mg) yield as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115122B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-2c4c73fc00254f39b1240ab5a2e91a03 |
| Source note | uspto-grants-2015_08 |