HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (Z)-5-(4-ethoxybenzylidene)-3-(pyridin-4-ylmethyl)thiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(Chloromethyl)pyridine | HCID 74571 | — |
| Reactant | (Z)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione | HCID 5878179 | — |
| Reactant | (Z)-5-(4-ethoxybenzylidene)-3-propylthiazolidine-2,4-dione | HCID 71697554 | — |
| Product | (Z)-5-(4-ethoxybenzylidene)-3-(pyridin-4-ylmethyl)thiazolidine-2,4-dione | HCID 71697661 | — |
Reaction Steps
The title compound 28l was prepared from compound 2 (75 mg, 0.30 mmol), 4-picolyl chloride.HCl (54 mg, 0.33 mmol), sodium iodide (45 mg, 0.30 mmol) and potassium carbonate (124 mg, 0.90 mmol) in a manner similar to that described for 28d in 96.1% (98 mg) yield as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115122B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-05e3eab09f0f4054b19cf3a4cea85607 |
| Source note | uspto-grants-2015_08 |