HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → (Z)-4-((5-(4-ethoxybenzylidene)-2,4-dioxothiazolidin-3-yl)methyl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(Bromomethyl)benzonitrile | HCID 86996 | — |
| Reactant | (Z)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione | HCID 5878179 | — |
| Reactant | (Z)-5-(4-ethoxybenzylidene)-3-propylthiazolidine-2,4-dione | HCID 71697554 | — |
| Product | (Z)-4-((5-(4-ethoxybenzylidene)-2,4-dioxothiazolidin-3-yl)methyl)benzonitrile | HCID 71697662 | — |
Reaction Steps
The title compound 28m was prepared from compound 2 (75 mg, 0.30 mmol), p-cyanobenzyl bromide (65 mg, 0.33 mmol) and potassium carbonate (83 mg, 0.60 mmol) in a manner similar to that described for 28d in 81.5% (89 mg) yield as a light-yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115122B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-ef0e5a284547439eb199d075eee84d95 |
| Source note | uspto-grants-2015_08 |