HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylbenzaldehyde → 3-(2-Aminoethyl)-5-[(4-methylphenyl)methylidene]-1,3-thiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylbenzaldehyde | HCID 7725 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 3-(2-Aminoethyl)-5-(phenylmethylidene)-1,3-thiazolidine-2,4-dione | HCID 1551244 | — |
| Reactant | 3-(2-(Tritylamino)ethyl)thiazolidine-2,4-dione | HCID 71697168 | — |
| Product | 3-(2-Aminoethyl)-5-[(4-methylphenyl)methylidene]-1,3-thiazolidine-2,4-dione | HCID 2432691 | — |
Reaction Steps
The title compound 30d was prepared from 4-methylbenzaldehyde (73 μL, 0.62 mmol), compound 29 (250 mg, 0.62 mmol) and piperidine (7.0 μL, 0.062 mmol) in a manner similar to that described for 30a in 36.0% (83 mg) yield as a cream solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115122B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-2f931743f34044309890919c7d598b28 |
| Source note | uspto-grants-2015_08 |