反应详情

To the title compound of step A (10.3 g, 20 mmol) in MeOH (50 mL) was added thionyl chloride (4.4 mL, 60 mmol). The reaction was heated at reflux overnight, cooled to rt and concentrated. Purification via silica gel chromatography (0-15% EtOAc in heptane) gave the title compound (1.9 g, 40%). MS (ESI) mass calcd. for C8H8BrNO2, 230.1; m/z found 232 [M+H]+.

1. temperatureThe reaction was heated
2. temperatureat reflux overnight
3. concentrationconcentrated
4. customPurification via silica gel chromatography (0-15% EtOAc in heptane)