Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane | HCID 11521263 | — |
| Reactant | HCID 43134746 | HCID 43134746 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 68297709 | HCID 68297709 | — |
Reaction Steps
To a solution of 5-(chloromethyl)-1-[4-(trifluoromethyl)phenyl]-1H-tetrazole (500 mg, 1.90 mmol, commercially available from UkrOrgSynthesis, Kiev, Ukraine) in acetonitrile (10 mL) was added 1,1-dimethylethyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (377 mg, 1.90 mmol, commercially available, for example from Sigma Aldrich Corporation) and triethylamine (0.796 mL, 5.71 mmol). The mixture was then heated to 120° C. for 20 min in a microwave reactor.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09115132B2 |
|---|
| Source dataset | uspto-grants-2015_08 |
|---|
| ORD ID | ord-8803241604b446fc8a536acf653fa60b |
|---|
| Source note | uspto-grants-2015_08 |
|---|
