Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (3R)-3-Methylpiperazin-2-one | HCID 16213757 | — |
| Reactant | HCID 43134746 | HCID 43134746 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 86691869 | HCID 86691869 | — |
Reaction Steps
To a solution of 5-(chloromethyl)-1-[4-(trifluoromethyl)phenyl]-1H-tetrazole (500 mg, 1.90 mmol, commercially available from UkrOrgSynthesis, Kiev, Ukraine) in acetonitrile (8 mL) was added triethylamine (0.796 mL, 5.71 mmol) and (3R)-3-methyl-2-piperazinone (239 mg, 2.09 mmol, commercially available, for example from Sigma Aldrich, St Louis, USA). The reaction mixture was heated to 120° C. for 20 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09115132B2 |
|---|
| Source dataset | uspto-grants-2015_08 |
|---|
| ORD ID | ord-1c2505e477bb4385937c24ba1a798e4d |
|---|
| Source note | uspto-grants-2015_08 |
|---|
