Formaldehyde → 4-({1-[4-(Trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)morpholine

Participants

Reaction Steps

To a solution of formaldehyde (37% in water) (0.074 ml, 1 mmol) in methanol (2 ml) was added morpholine (0.087 ml, 1.000 mmol). The reaction mixture was stirred at room temperature for 2 hours before the addition of trimethylsilylazide (0.159 ml, 1.200 mmol) and 4-(trifluoromethyl)phenyl isocyanide (0.205 g, 1.200 mmol). The reaction mixture was stirred at room temperature for 45 hours.

Provenance & Evidence