Formaldehyde → HCID 86691884, compound

Participants

Role	Name	HCID	Charge
Reactant	Formaldehyde	HCID 712	—
Reactant	Azidotrimethylsilane	HCID 78378	—
Reactant	4-Isocyanobenzonitrile	HCID 449775	—
Reactant	2,6-Dimethylmorpholine, cis-	HCID 641500	—
Solvent	Methanol	HCID 887	—
Product	HCID 86691884	HCID 86691884	—

Reaction Steps

To a solution of (cis)-2,6-dimethylmorpholine (104 mg, 0.9 mmol, Alfa Aesar, Ward Hill, USA) in methanol (3 mL) was added formaldehyde (37% aqueous) (0.067 mL, 0.900 mmol). The reaction mixture was shaken at room temperature for 40 minutes. To the reaction mixture was added 4-isocyanobenzonitrile (128 mg, 1 mmol) and trimethylsilylazide (0.133 mL, 1.00 mmol). The reaction mixture was shaken at room temperature for a further 18 hours.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09115132B2
Source dataset	uspto-grants-2015_08
ORD ID	ord-720aed0b4b594a40bf1da4a6a910753d
Source note	uspto-grants-2015_08