HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 517770Generated: November 1, 2026
Triethylamine → 4-({1-[3-(Trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-2-piperazinone
https://huagongshe.com/reaction/517770
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Piperazin-2-one | HCID 231360 | — |
| Reactant | 5-(Chloromethyl)-1-(3-(trifluoromethyl)phenyl)-1H-tetrazole | HCID 8027175 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-({1-[3-(Trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-2-piperazinone | HCID 56600138 | — |
Reaction Steps
To a solution of 5-(chloromethyl)-1-[3-(trifluoromethyl)phenyl]-1H-tetrazole (400 mg, 1.52 mmol, commercially available from Otava, Kiev, Ukraine) in acetonitrile (5 mL) was added triethylamine (0.637 mL, 4.57 mmol) and 2-piperazinone (168 mg, 1.675 mmol, Sigma-Aldrich). The reaction mixture was heated to 120° C. for 20 min in a microwave reactor.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09115132B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-81f2b5486216449eaf32dbece6e4bf76 |
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| Source note | uspto-grants-2015_08 |
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